ea0063gp9 | Adrenal and Neuroendocrine - Tumour | ECE2019
Kyriakopoulos Georgios
, Nasiri-Ansari Narjes
, Angelousi Anna
, Philippou Anastasios
, Karapanagioti Angeliki
, Zografos Georgios
, Aggeli Chrysanthi
, Choreftaki Theodosia
, Tiniakos Dina
, Rontogianni Dimitra
, Dimitriadis Georgios
, Kaltsas Gregory
, Papavassiliou Athanasios G.
, Kassi Eva
Introduction: IGF-1 overexpression has been associated with tumorigenesis. IGF-1Ea, IGF-1Eb and IGF-1Ec isoforms were shown to be regulated differently in cancer. IGF-1Ec and IGF-1Eb overexpression has been positively associated with cell survival and proliferation in various tumors. Elevated IGF1Eb/IGF-1Ea ratio has been suggested as a biomarker of cervical cancer prognosis. Herein, we aimed to examine the expression of IGF-1 isoforms in human adrenocortical carcinomas (ACCs)...